HLA-monomorphic determinants of the primary tumor in breast cancer patients

Background . Molecules of the major histocompatibility complex in cancer are currently being widely studied, and their clinical significance is still subject controversy. It reported that they might have an important predictive value effectiveness immunotherapy. The study expression HLA molecules status breast provides a deeper understanding biological properties tumor, particular to identify features its immunological phenotype, which may further influence on therapy. Aim To evaluate frequency HLA-immunophenotypes relationship with morphological primary tumor. Materials methods This included 82 patients who received treatment at N.N. Blokhin National Medical Research Center Oncology, Ministry Health Russia. Immunophenotyping tumor was performed by immunofluorescence cryostat sections. reaction evaluated using ZEISS Axioscope 5 luminescent microscope (Zeiss AG, Germany). dominated stage IIB 54 %, IIA detected % cases, IIIA – 12 IIIB 21 IIIC 8 %. Infiltrative ductal diagnosed 67 ( n = 55), infiltrative-lobular 22 cases 18), other types 11 9). immunophenotypes studied depending characteristics cancer. Results found group as whole, HLA-binegative immunophenotype predominant. T4 compared HLA-I + /HLA-DR phenotype (100 0 %), p 0.042. At same time, it should be noted also observed. this stage: higher than 60 40 0.01. Both HLA-DR-negative were characterized high incidence lymph node involvement absence estrogen receptor expression. 80 receptor-negative tumors , 0.022; similar data obtained for 0.037). Conclusion analysis revealed second most common HLA-DR molecules. association process, size receptors revealed.